| Notes |
The three most upstream rot promoters are activated by the global gene regulatory cAMP-CRP complex and negatively regulated by the CytR repressor protein. Activation of these three promoters occurs by binding of cAMP-CRP to two sites separated by 53bp. The nucleotide sequence upstream of each of the four putative start sites for transcription contains a good match to the Sigma70 -10 sequence. Moreover, the putative rotp1 promoter contains a sequence with partial homology to the Sigma70 -35 sequences. |